|Friends||Master Hand, Crazy Hand|
|Enemies||Mario, Luigi, Pikachu, Link, etc.|
|Likes||Master Hand, Crazy Hand|
|First appearance||Super Smash Bros. Plush Ep. 6: Meeting of the Hands|
|Latest appearance||Super Smash Bros. Plush Ep. 7: Gathering at Outset Island|
Mewtwo is one of the main villains of Super Smash Bros. Plush. Out of the villains, he is the most well-liked by Master Hand. While the rest of the villains were struck by Master Hand's laser in Super Smash Bros. Plush Ep. 7: Gathering at Outset Island, Mewtwo was spared.